Occupational Risk Factors and Mental Health Among Frontline Health Care Workers in a Large US Metropolitan Area During the COVID-19 Pandemic

Prim Care Companion CNS Disord 2022;24(2):21m03166

To cite: Cahill AG, Olshavsky ME, Newport DJ, et al. Occupational risk factors and mental health among frontline health care workers in a large US metropolitan area during the COVID-19 pandemic. Prim Care Companion CNS Disord. 2022;24(2):21m03166.
To share: https://doi.org/10.4088/PCC.21m03166

© Copyright 2022 Physicians Postgraduate Press, Inc.

^aDepartment of Women’s Health, University of Texas at Austin, Dell Medical School, Austin, Texas
^bAscension, St Louis, Missouri
^cDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, Dell Medical School, Austin, Texas
^dDepartment of Surgery and Perioperative Care, University of Texas at Austin, Dell Medical School, Austin, Texas
^eDepartment of Population Health, University of Texas at Austin, Dell Medical School, Austin, Texas
^fUniversity of Texas at Austin, Austin, Texas
*Corresponding author: Alison G. Cahill, MD, MSCI, Department of Women’s Health, University of Texas at Austin, Dell Medical School, 1601 Trinity St, Austin, TX 78712 ([email protected]).

“See letter by La Tegola et al”

The psychological strain on essential health care workers during the coronavirus disease 2019 (COVID-19) pandemic has been well documented in both the lay press and the scientific literature. Research from multiple countries has documented high burden of anxiety, depression, burnout, posttraumatic stress disorder (PTSD), and other measures of psychosocial stress among health care workers during the pandemic.¹ The literature is substantial enough to support the conduct of systematic reviews and meta-analyses,^1,2 which have documented 20%–30% pooled prevalence estimates for anxiety and depression.

Prior work on the psychological impact of pandemics on health care workers has been from lessons learned during influenza pandemics and prior outbreaks of earlier coronaviruses.^3–5 Existing literature to date on the impact of the COVID-19 pandemic has focused primarily on health care workers in countries outside of the United States, and the few studies among frontline health care workers in the United States estimated mental health outcome prevalence only during the earlier months of the pandemic.^6–9 Because there is scant information about the mental health toll among US frontline health care workers over the subsequent months of the pandemic, it is unclear whether the mental health distress documented in the earlier days of the pandemic has persisted throughout. In addition, the international literature has identified occupational risk factors for worse mental health, including reuse of personal protective equipment (PPE),¹⁰ yet there is limited literature on occupational mental health risk factors among US health care workers.

We therefore conducted a survey of frontline health care workers from 2 health systems in central Texas to assess depression, anxiety, and burnout using well-established validated scales and to examine associations of these mental health outcomes with PPE and high-risk patient contact.

METHODS

Study Population

Staff, both clinical and nonclinical, of 2 health care systems in Texas were invited via e-mail to participate in an online survey. E-mail invitations were sent in 4 waves between August and October 2020. Individuals who had not completed the survey received reminder e-mails 8 days after the first invitation and then again 8 days after that if they did not respond. A total of 17,125 invitations were sent, and 970 individuals completed at least part of the survey. Study team members were blind to participant identifiers and employers, which was explained to potential participants in the cover letter. The study was submitted to the University of Texas at Austin Institutional Review Board and was determined to be exempt.

Survey

The survey captured basic demographic, occupational, and baseline health information including a history of mental health disorders, in addition to the validated mental health scales described here.

Baseline PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5).¹¹ The survey was available in both English and Spanish; 99.8% completed the English version and 0.2% completed the Spanish version.

Depression was assessed with the 8-item Patient Health Questionnaire (PHQ-8),¹² which is a validated diagnostic and severity assessment tool for depression in adults. Scores range from 0 to 20, with cut points for no depression, as well as mild, moderate, and severe depression of < 5, 5–9, 10–14, and ≥ 15, respectively.

Generalized anxiety was assessed with the 7-item Generalized Anxiety Disorder Scale (GAD-7),¹³ which is a validated screening tool for generalized anxiety disorder. Scores < 5, 5–9, 10–14, and ≥ 15 are indicative of no, mild, moderate, and severe anxiety, respectively.

Burnout was evaluated using the 23-item Burnout Assessment Tool (BAT-23),¹⁴ which is a validated tool for assessing risk of problematic burnout. Scores of 1–2.58, 2.59–3.01, and 3.02–5.0 represent no risk, at risk, and at very high risk of burnout.

Questions about clinical contact with patients with suspected or known COVID-19 were incorporated, including the number of hours in contact with such patients in the past week. Questions about provision of PPE and confidence in the adequacy of PPE were also included. These questions were as follows:

Statistical Analyses

Descriptive statistics were generated for participant demographics and characteristics. Both single and multiple regression models were fitted to the data to estimate associations of each of 3 mental health outcome scales (PHQ-8, GAD-7, and BAT-23) to reported confidence in adequacy of PPE and reported contact hours in the past week with COVID patients undergoing aerosol-generating procedures. The contact hours predictor variable was log-base-2 transformed so that the fitted coefficient represents the expected proportional increase in the mental health response variable for each doubling of the predictor. All regression analyses used a generalized linear density ratio model with identity link^15,16 fitted to the data for each of the 6 pairs of outcome and primary predictor. This model yields identical interpretations of regression coefficients as those in a standard linear regression model, with more statistically robust hypothesis tests and confidence intervals. Four different models were fitted to each outcome and primary predictor pair. First, a single predictor model tested for a linear trend between the outcomes and predictors of interest. Multiple regression models were fitted sequentially to test whether the addition of more adjusters modified the relationship of the outcome to the primary predictor. Model 1 included age, gender, and education as adjusters. Then, participant role and history of emotional or mental health problems were added subsequently in models 2 and 3, respectively.

Gender was categorized as male, female, and other, which included transgender male and female, nonbinary, other, and “prefer not to answer” responses. Race included White, Asian, more than 1 race, Black or African American, and other, which included American Indian or Alaska Native, Native Hawaiian or Other Pacific Islander, and “prefer not to answer” responses. For the mental health scales (PHQ-8, GAD-7, and BAT-23), if a participant completed only part of a particular scale, missing values were imputed by random sampling from the distribution of non-missing responses for that question; such item-level missingness was relatively rare. For the PHQ-8, GAD-7, and BAT-23, there were only 28, 26, and 59 participants who had at least 1 response imputed for totals of 30, 31, and 136 total item-level responses imputed for each scale, respectively. If a participant did not answer any of the questions for a given mental health scale, missing values were not imputed; rather, that participant was not included in analyses for that scale. Finally, to interpret the results in the setting of the COVID-19 admission census in central Texas, PHQ-8, GAD-7, and BAT-23 scores were plotted against the daily hospitalizations for COVID-19 in the Austin metropolitan area. All statistical analysis was performed using R Statistical Software version 4.0.2.

RESULTS

A total of 970 people participated in the study. The mean age of the study population was 41.5 years (SD = 11.1), and 83.5% were female (n = 802). The distribution of race was 81.9% White (n = 784), 5.9% Asian (n = 56), 4.5% more than 1 race (n = 43), and 4.0% Black or African American (n = 38), and 17.5% were of Hispanic ethnicity (n = 169). The distribution of participant role was 43.0% nurses (n = 379), 21.5% physicians/advanced care practitioners (n = 190), 9.5% administration/administrative support (n = 84), 4.6% occupational/physical/respiratory therapy (n = 41), 2.9% psychology and social work (n = 26), 2.5% laboratory technicians (n = 22), 1.1% facilities/IT/security (n = 10), and 0.7% paramedics (n = 6). Approximately 24% had moderate or severe anxiety, 14% had moderate or severe depression, and 7% were at high risk for burnout (Table 1).

Unadjusted analysis showed that the PHQ-8, GAD-7, and BAT-23 all have a statistically monotonic trend with confidence in PPE adequacy (P < .001, P < .001, P < .001, respectively) as well as with reported patient contact hours during aerosol-generating procedures (P < .002, P < .008, P < .002, respectively) (Figure 1).

For the predictor of perceived PPE adequacy (Table 2), model 1, which includes age, gender, and education as adjusters, showed statistically significant associations with all 3 mental health outcomes. The PHQ-8 score, on average, increased by 0.52 (95% CI, 0.13–0.92) for each level difference in perceived PPE inadequacy. The GAD-7 score, on average, increased by 1.01 (95% CI, 0.57–1.45) for each level difference in perceived PPE inadequacy. The BAT-23 score, on average, increased by 0.12 (95% CI, 0.06–0.19) for each level difference in perceived PPE inadequacy. These relationships were not significantly impacted with the sequential addition of health care role and history of emotional or mental health problems as adjuster variables in models 2 and 3 (Supplementary Figure).

The predictor of number of contact hours with patients during aerosol-generating procedures, model 1, which includes age, gender, and education as adjusters, showed statistically significant associations with the GAD-7 and BAT-23 scores (Table 2). On average, a 2:1 relative difference of contact hours was associated with an increase in GAD-7 score by 0.18 (95% CI, 0.02–0.33) and BAT-23 score by 0.02 (95% CI, 0.00–0.05). These relationships were not significantly impacted with the sequential addition of role and history of emotional or mental health problems as adjusters in models 2 and 3. In model 1, PHQ-8 score was not significantly associated with contact hours; however, this relationship was statistically significant in models 2 and 3 with the sequential addition of role and history of emotional or mental health problems as adjusters. Model 2 showed an average PHQ-8 increase of 0.15 (95% CI, 0.01–0.30) associated with a doubling of contact hours. The 3 mental health outcomes were strongly correlated with one another with correlation coefficients between 0.62 and 0.70 (Table 3).

Finally, to interpret the results in the setting of the COVID-19 admission census in central Texas, PHQ-8, GAD-7, and BAT-23 scores were plotted against the daily hospitalizations for COVID-19 in the Austin metropolitan area (Figure 2).

DISCUSSION

Overall, the prevalence of moderate to severe anxiety was similar in this study population to that reported previously in other populations, but the prevalence rates of depression and burnout were lower. In addition, perception of PPE adequacy was inversely correlated with measures of depression, anxiety, and burnout among essential members of 2 health care systems whose roles precluded working remotely during the pandemic. These associations persisted even when adjusting for role in the health care system and level of education, as well as accounting for reported baseline mental health disorders preceding the pandemic. In addition, hours of contact with COVID-19 patients during aerosolizing procedures was positively correlated with measures of anxiety and burnout in all models and with depression after adjustment for age, gender, and occupational role. Among participants in our study, the majority were female, and the most common roles in the health care system were nurses, physicians, and advanced practitioners. However, we considered the health care system as a whole and defined essential workers broadly to include other essential roles such as facilities support and administration, which few prior studies have done.

An early study¹⁷ of health care workers in China in January–February 2020 across 34 hospitals reported significant psychological burden during the COVID-19 pandemic. The authors¹⁷ described evidence of depression, insomnia, and distress, particularly among nurses. A recent meta-analysis² of 25 cross-sectional studies found that nurses from around the world showed high rates of poor mental health outcomes, including depression, anxiety, and stress during the pandemic. However, the authors² were unable to comment on the impact of the pandemic on burnout because it was understudied. Our study similarly demonstrated high rates of depression and anxiety, as well as burnout, not only among nurses but also among workers in other essential health care roles.

A study¹⁸ of health care workers during May 2020 explored occupational risks of adverse psychiatric outcomes in the northeast and southern United States. The researchers¹⁸ found that providing care for inpatients or in the emergency department was a risk factor for COVID-19 infection, as well as depression, anxiety, and burnout, but they did not explore the impact of perceived PPE adequacy or contact with COVID-19 patients during aerosolizing procedures on mental health. A global study¹⁹ of health care workers examined occupational factors that contributed to burnout. The authors¹⁹ found that reported adequate PPE was only 54.8%, but that adequacy was positively correlated with a reduction in risk of burnout. However, only 30.8% of participants were from the United States, and the study was conducted in April 2020, which was early in the pandemic’s impact on the United States. This study¹⁹ also did not examine exposure to aerosolizing procedures as a mental health risk factor. A study²⁰ of 55 health care workers in March to April 2020 in urban Washington, DC identified lack of PPE as a risk factor for increased stress and burnout. As the pandemic continued into the summer of 2020 in the United States, PPE became more widely available to essential health care workers.²⁰

In a large tertiary care hospital in New York, New York, during the initial COVID-19 surge, frontline health care workers reported that perceived support from hospital leadership reduced the psychological impact of the pandemic.²¹ Similarly, a Cochrane meta-analysis²² of 16 studies of factors impacting the mental well-being of essential workers during disease epidemics highlighted the importance of effective communication from organizations for whom they worked. The majority of participants in our study reported that they felt somewhat confident or very confident that their PPE was adequate, despite that it was conducted before the availability of COVID-19 vaccines in central Texas. Given the literature indicating the important role of workplace characteristics such as perceived support and effective communication in mitigating the mental health impact of COVID-19 on health care workers, we hypothesize that these findings may be due, at least in part, to the responses of these health care systems. For example, the health care systems prioritized providing PPE to their essential workers when there were national shortages and communicated regularly about ways their employees were being cared for including access to PPE and ongoing planning. These health systems also rapidly developed systems to train essential workers in the proper use of PPE. Additional studies examining the steps health care systems can take to mitigate the mental health toll on health care workers are needed to develop a better understanding of how health care systems can most effectively support essential workers during a pandemic.

Our study contributes to the existing literature regarding mental health of health care workers during the COVID-19 pandemic in the United States. The broad definition of essential workers allowed us to consider the impact on many members of the health care team, not just patient-facing members. The protections of participant privacy were put in place to encourage participation and honesty. Finally, we used validated tools to measure depression, anxiety, and burnout. There are also potential limitations to consider. Despite our attempt to survey across health care roles, most participants were patient-facing providers, and, thus, generalizability may be limited. While a large number of employees responded, they only represented 5.6% of the potential participants. Finally, in an effort to limit participant burden, we reduced the number of questions, but by doing so we were unable to ask about several other areas of interest including shifting roles and specific health care units (ie, intensive care unit) that might have impacted mental health.

Despite these potential limitations, this study contributes to our understanding of the impact of the COVID-19 pandemic on the mental health of essential health care workers. It also highlights the correlations of perceptions of PPE adequacy and contact hours with COVID-19 patients undergoing aerosolizing procedures and employee mental well-being. Future work confirming our findings across a diverse array of essential health care roles can help identify ways that systems can support their employees through similarly stressful and demanding events.

Submitted: October 1, 2021; accepted January 10, 2022.
Published online: March 8, 2022.
Relevant financial relationships: Dr Newport has received research support from Eli Lilly, GlaxoSmithKline, Janssen, the National Alliance for Research on Schizophrenia and Depression, the National Institutes of Health, Sage Therapeutics, Takeda, the Texas Health & Human Services Commission, and Wyeth; has served on speakers’ bureaus and/or received honoraria from AstraZeneca, Eli Lilly, GlaxoSmithKline, Pfizer, and Wyeth; and has served on advisory boards for GlaxoSmithKline, Janssen, and Sage Therapeutics. The efforts of Dr Rathouz and Mr Custer on this project were supported by core funds of the Dell Medical School at the University of Texas at Austin. Drs Cahill, Olshavsky, Benzer, Leslie, and Matsui and Mss Chambers, Nutt, and Jwaied report no financial relationships relevant to the subject of this article.
Funding/support: None.
Supplementary material: See accompanying pages.

Clinical Points

• Perceptions of adequacy of personal protective equipment can impact health care worker mental health.
• Number of hours in contact with patients with COVID-19 during aerosolizing procedures is correlated with health care worker anxiety.