This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.
Letter to the Editor
Novel Use of Tramadol Hydrochloride in the Treatment of Tourette’s Syndrome
Published: April 15, 1997
Letter to the Editor
Sir: Studies have demonstrated that symptoms of Tourette’s
syndrome can be attenuated by modulation of the opioid system.
However, the response to opioid agonists or antagonists
is often limited by side effects and the development of tolerance.
Additionally, these compounds have significant abuse potential.
The opioid tramadol hydrochloride (Ultram) has low abuse potential,
low physical dependency, and mild tolerance. It binds to
opioid receptors and also inhibits the reuptake of norepinephrine
and serotonin. We report the successful use of tramadol in the
treatment of a patient with severe Tourette’s syndrome.
Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.
Quick Links: