This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Educational Activity

Augmentation and Combination Strategies for Complicated Depression

Maurizio Fava, MD

Published: November 15, 2009

Article Abstract

Approximately half of patients with depression do not respond or only partially respond to first-line antidepressant monotherapy. To enhance treatment response, the treating clinician may choose to augment the antidepressant with a nonantidepressant agent or combine the initial antidepressant with another antidepressant, typically of another class. Although the augmentation and combination strategies reviewed here appear relatively safe and effective, additional controlled studies are needed to compare these treatment options, guide treatment selection for individual patients, and answer questions regarding the duration of combination or augmentation strategies for patients with treatment-resistant depression.

See the entire activity.‘ ‹


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 70

Quick Links: Bipolar Disorder , Complementary and Alternative Medicine

References