This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Article

Disrupted Default Mode Network and Basal Craving in Male Heroin-Dependent Individuals: A Resting-State fMRI Study

Qiang Li, PhD; Zhe Li, MD; Wei Li, MD; Yi Zhang, PhD; Yarong Wang, PhD; Jia Zhu, PhD; Jiajie Chen, MD; Yongbin Li, MD; Xuejiao Yan, MD; Jianjun Ye, PhD; Linbin Li, MD; Wei Wang, PhD; and Yijun Liu, PhD

Published: October 26, 2016

Article Abstract

Background: Craving is associated with a high probability of relapse. However, the relationship between functional connectivity in the default mode network (DMN) during resting state and basal craving of heroin-dependent individuals remains unknown.

Methods: Data used in the present study were collected between August 10, 2009, and June 28, 2011. Twenty-four male heroin-dependent individuals based on DSM-IV criteria and 20 male healthy control subjects participated in a study of resting-state functional magnetic resonance imaging. The basal heroin craving of the heroin-dependent group was evaluated. The DMN networks were identified by group independent component analysis. The between-group difference in functional connectivity was analyzed, and the relationship between functional connectivity in the DMN and basal heroin craving in the heroin-dependent group was also analyzed.

Results: In all subjects, 2 spatially independent default mode subnetworks were identified: the anterior and posterior subnetworks. The anterior subnetwork, mainly the dorsal medial prefrontal cortex, showed decreased functional connectivity in the heroin-dependent group relative to the healthy control group (P < .05, familywise error corrected). However, the functional connectivity in dorsal medial prefrontal cortex was negatively correlated with the basal craving of the heroin group (P = .01, r = −0.50). No significant difference in the functional connectivity of the posterior subnetwork was found.

Conclusions: Our findings suggest that abnormal functional connectivity within the anterior subnetwork of DMN in heroin-dependent individuals is associated with basal heroin craving, and it may serve as neural underpinnings for the mechanism of heroin addiction.

Volume: 77

Quick Links: Assessment Methods , Neuroimaging

Continue Reading…

Subscribe to read the entire article

$40.00

Buy this Article as a PDF

References