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Letter to the Editor

Methylphenidate-Induced Neuroleptic Malignant Syndrome: A Case Report

Biju Basil, MD, DPM Maju Mathews, MD, MRCPsych

Published: February 15, 2006

Article Abstract

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Sir: Methylphenidate is a piperidine derivative, structurally related to amphetamines. It reaches peak blood concentration in 2 hours and has a short half-life of 1 to 2 hours. Its onset of action occurs shortly after dosing, and it can cause increased wakefulness, energy, alertness, and physical and mental performance. Its side effects include anorexia, weight loss, slow growth, insomnia, dysphoria, tics, and psychosis.


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Quick Links: Neuroleptic Malignant Syndrome , Side Effects-Medication

References