This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letter to the Editor

Early Bicarbonate Loading and Dantroline for Ziprasidone/Haloperidol-Induced Neuroleptic Malignant Syndrome

Jeffrey R. Strawn, MD, and Paul E. Keck, Jr., MD

Published: April 15, 2006

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: Neuroleptic malignant syndrome (NMS), when severe, is associated with a 10% mortality rate.1 Many patients exhibit renal dysfunction often due to myoglobinuric renal failure secondary to rhabdomyolysis.1 In one series of cases of severe NMS, over 50% progressed to renal failure.2 Randomized controlled trials of early and preventive alkalinization with sodium bicarbonate have demonstrated protective effects in patients at risk for contrast-induced nephropathy,3 as well as protection against nephropathy in patients with early rhabdomyolysis, a variety of intoxication states, and acute ischemic renal failure in animal models.4‘ ‹


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 67

Quick Links: Neuroleptic Malignant Syndrome , Side Effects-Medication